01 November 2018

Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage

DOI : 10.3390/ijms19113599

Cristian Cortez, PhD.

Niemann⁻Pick type C (NPC) disease is a rare neurovisceral cholesterol storage

disorder that arises from loss of function mutations in the NPC1 or NPC2 genes.

Soon after birth, some patients present with an aggressive hepatosplenomegaly

and cholestatic signs. Histopathologically, the liver presents with large

numbers of foam cells; however, their role in disease pathogenesis has not been

explored in depth. Here, we studied the consequences of gadolinium chloride

(GdCl₃) treatment, a well-known Kupffer/foam cell inhibitor, at late stages of

NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in

vivo. GdCl₃ treatment successfully blocked the endocytic capacity of hepatic

Kupffer/foam measured by India ink endocytosis, decreased the levels CD68-A

marker of Kupffer cells in the liver-and normalized the transaminase levels in

serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue

of liver cells. Gadolinium salts are widely used as magnetic resonance imaging

(MRI) contrasts. This study opens the possibility of targeting foam cells with

gadolinium or by other means for improving NPC liver disease. Synopsis:

Gadolinium chloride can effectively rescue some parameters of liver dysfunction

in NPC mice and its potential use in patients should be carefully evaluated.

Participating Center Researchers

Host-Pathogen Interactions Laboratory

PhD in Sciences, mention Microbiology, Inmunology, and Parasitology, Universidade Federal de São Paulo, Brasil.



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