Rodrigo Maldonado, PhD.

Principal Investigator and Assistant Professor

Laboratorio de Biología Celular y Molecular Aplicada (Labcema)

PhD in Sciences, mention Molecular and Cell Biology, Universidad de Regensburg, Alemania and Universidad Austral de Chile, Chile.

Líneas de Investigación

Laboratorio de Biología Celular y Molecular Aplicada (Applied Cell Biology and Molecular Lab)

Non-coding RNAs (ncRNAs) are able to regulate gene expression through different mechanisms. One of them, is due to the direct/indirect interaction with chromatin. Our Laboratory is focused on the understanding of chromatin-RNA interactions at the molecular level and their effects on gene expression, using different cell types and disease models. We are particularly interested in determining how long- and short-ncRNAs are interacting with different chromatin marks regulating key genes associated with the progression of tumorigenic cells. Our long-term aim is to expand to other diseases in order to develop treatments based on antisense oligonucleotides. Our laboratory of was recently settled at the Universidad Mayor in Temuco and we are supported with the funding of Fondecyt (Fondecyt Iniciación RM 11190246) and the Center of Genomics and Bioinformatics (CGB). Our group is highly motivated and currently looking for undergraduate, master and PhD students to develop the current projects.


Dr. Maldonado obtained his Biochemist title from the Universidad Austral de Chile, and then his doctoral degree in Sciences mention Celular and Molecular Biology from a binational PhD program from the Universität Regensburg (Regensburg, Germany) and the Universidad Austral de Chile. During his PhD, Dr. Maldonado worked in Valdvia with Dra. Ilona Concha G. on a project related to a novel function of a metabolic enzyme interacting with RNA, in association with Prof. Dr. Gernot Längst at the Universität Regensburg. Additionally, he made international internships to the Institute Pasteur in Paris, France, and the Laboratory of Raúl Mendez in the Institute of Research in Biomedicine in Barcelona, Spain. Then he did his postdoctoral training in the laboratory of Prof. Dr. Gernot Längst, working in chromatin remodelers and deciphering the molecular determinants of ncRNA-chromatin interactions through triple helices, highlighting one publication that for the first time described the formation of these structures in human cells using different methods related to high-throughput sequencing.



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