Mauricio Sáez, PhD.

Investigador Principal, Profesor Asistente

Chromatin, Epigenetic and Neuroscience

Doctor en Biología Molecular y Celular, Universidad Austral de Chile.

mauricio.saez@umayor.cl

Líneas de Investigación

  • Modulación del Complejo Represivo Polycomb 2 en la maduración del sistema nervioso, se analiza el efecto modulador de Huntingtina en la actividad catalítica y localización genómica del Complejo, las implicancias fisiológica de esta modulación y fisiopatológicas que ocurren durante el desarrollo de la enfermedad de Huntington.
  • Como líneas secundarias se estudia el efecto de la reparación del DNA en la maduración del sistema nervioso y el efecto en trastornos del espectro autista.

Chromatin, Epigenetic and Neuroscience

Our research is focused in epigenetic mechanisms to control the chromatin´s structure and genes expression in nervous system. We study the scarcely characterized function of Polycomb Repressive Complex 2 (PRC2) in postmitotic cell, using the neuron as model. PRC2 has been widely studied for set and maintain a repressive state of chromatin in early stage of embryonic development and linage commitment, but its function in postmitotic cell is poorly understood. To assess our objectives we combine chromatin immunoprecipitation with the last technologies of DNA sequencing to determinate the role of PRC2 and their associated proteins in the control of chromatin beyond the traditional analysis on transcription start site. Specific, we study the modulation of PRC2 by Huntingtin, a scaffold protein with ubiquitous expression and whose mutation are responsible of Huntington disease, a severe cognitive, motor a psychiatric disorder with fatal outcome. Understand the epigenetic alteration in this and other neurological disorders is the purpose of our team.

Edificio2

Contact

Corporate building, first underground - Campus Huechuraba - Camino La Pirámide 5750, Huechuraba
+56 223 281 323|cgbum@umayor.cl